APPLICATION
PROPERTIES
Form
Lyophilized powder
Buffer
Batch dependent (please contact us for details)
Storage
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.
Region/Sequence
N-terminal poly His and GST tagged; Met1-Thr934 of Human MSH2 protein (NP_000242.1)
Expression System
Baculovirus (Insect cells)
Purity
> 90% by SDS-PAGE.
Endotoxin
< 1.0 EU/μg (determined by LAL method)
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
COCA1,FCC1,HNPCC,HNPCC1,LCFS2,hMSH2
Background
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Database
Research Area
DATA IMAGES
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GTX01326-pro Image
SDS-PAGE of 5 μg GTX01326-pro Human MSH2 protein, GST and His tag.
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REFERENCE
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REVIEW
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