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United States (US)

Human PDGF-AB protein (active)

Cat No. GTX00390-pro

Application Functional Assay
Species Human
Package
10 μg ($199)
PRODUCT

Product Description

Platelet Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle and connective tissue. PDGF, which is composed of a dimer of two chains termed the A chain and B chain, can be present as AA or BB homodimers or as an AB heterodimer. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids). Verified by N-terminal and Mass Spectrometry analyses (when applicable).
APPLICATION

Application Note

The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶units/mg.

Specificity/Sensitivity

cross reactivity: Monkey, Mouse
PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

Region/Sequence

Alpha chain: MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT
Beta chain: MSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIGIVR KKPIFKKATV TLGDHLACKC ETVAAARPVT

Expression System

E. coli

Purity

≥ 98% by SDS-PAGE and HPLC.

Endotoxin

< 1 EU/μg

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

platelet derived growth factor subunit A,platelet derived growth factor subunit B,PDGF-A,PDGF1,IBGC5,PDGF-2,PDGF2,SIS,SSV,c-sis

Database

  • Gene ID: 5154 PDGFA
  • Gene ID: 5155 PDGFB

Research Area

REFERENCE
There are currently no references for Human PDGF-AB protein (active) (GTX00390-pro). Be the first to share your publications with this product.
REVIEW
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Package List Price ($)
$ 199