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Human PTPN12 protein, His tag and GST tag (active)

Human PTPN12 protein, His tag and GST tag (active). GTX03561-pro

Cat. No. GTX03561-pro

Application

 Functional Assay

Species

 Human
Package
100 μg ($399)
See all PTPN12 protein products

APPLICATION

Application Note

Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate. The specific activity is > 15 μmoles/min/mg.

Observed MW

64 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Region/Sequence

N-terminal polyhistidine and GST tag; Met1-Gln355 (AAA36529.1)

Expression System

Baculovirus-Insect Cells

Purity

> 90 % by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

protein tyrosine phosphatase non-receptor type 12 , PTP-PEST , PTPG1

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES

Human PTPN12 protein, His tag and GST tag (active). GTX03561-pro

GTX03561-pro Image

SDS-PAGE of GTX03561-pro human PTPN12 protein, His tag and GST tag (active).

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Package List Price ($)
$ 399