20 mM Tris buffer (pH 8.0) with 10% glycerol, 1 mM DTT, 0.1 M NaCl.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Full length protein, N-terminal His-Tag; MGSSHHHHHH SSGLVPRGSH MGSHMSTGGD FGNPLRKFKL VFLGEQSVGK TSLITRFMYD SFDNTYQATI GIDFLSKTMY LEDRTIRLQL WDTAGQERFR SLIPSYIRDS AAAVVVYDIT NVNSFQQTTK WIDDVRTERG SDVIIMLVGN KTDLADKRQV SIEEGERKAK ELNVMFIETS AKAGYNVKQL FRRVAAALPG MESTQDRSRE DMIDIKLEKP QEQPVSEGGC SC
> 90% by SDS-PAGE.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
RAB6A, member RAS oncogene family , RAB6
Golgi apparatus membrane
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]