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Human RASD2 protein, His tag

Human RASD2 protein, His tag. GTX68332-pro

Cat No. GTX68332-pro

Species

Human
Package
100 μg ($289)

APPLICATION

Observed MW

30 kDa.

PROPERTIES

Form

Liquid

Buffer

20 mM Tris-HCl buffer (pH 8.0) with 10% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Region/Sequence

Full length protein, N-terminal His-Tag; MGSSHHHHHH SSGLVPRGSH MGSMMKTLSS GNCTLSVPAK NSYRMVVLGA SRVGKSSIVS RFLNGRFEDQ YTPTIEDFHR KVYNIRGDMY QLDILDTSGN HPFPAMRRLS ILTGDVFILV FSLDNRESFD EVKRLQKQIL EVKSCLKNKT KEAAELPMVI CGNKNDHGEL CRQVPTTEAE LLVSGDENCA YFEVSAKKNT NVDEMFYVLF SMAKLPHEMS PALHRKISVQ YGDAFHPRPF CMRRVKEMDA YGMVSPFARR PSVNSDLKYI KAKVLREGQA RERDKCTIQ

Expression System

E.coli

Purity

> 85% by SDS-PAGE.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

RASD family member 2 , Rhes , TEM2

Cellular Localization

Cell membrane

Background

This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Human RASD2 protein, His tag. GTX68332-pro

GTX68332-pro Image

3μg Human RASD2 protein (GTX68332-pro) by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Package List Price ($)
$ 289