Form
Liquid
Buffer
20mM Tris-HCl, 10% Glycerol
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Region/Sequence
Full length protein, N-terminal His-Tag; MGSSHHHHHH SSGLVPRGSH MGSMMKTLSS GNCTLSVPAK NSYRMVVLGA SRVGKSSIVS RFLNGRFEDQ YTPTIEDFHR KVYNIRGDMY QLDILDTSGN HPFPAMRRLS ILTGDVFILV FSLDNRESFD EVKRLQKQIL EVKSCLKNKT KEAAELPMVI CGNKNDHGEL CRQVPTTEAE LLVSGDENCA YFEVSAKKNT NVDEMFYVLF SMAKLPHEMS PALHRKISVQ YGDAFHPRPF CMRRVKEMDA YGMVSPFARR PSVNSDLKYI KAKVLREGQA RERDKCTIQ
Expression System
E. coli
Purity
> 85% by SDS-PAGE.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
RASD family member 2 , Rhes , TEM2
Cellular Localization
Cell membrane
Background
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
Database
Research Area