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Human Renin protein, His tag

Human Renin protein, His tag. GTX01282-pro

Cat No. GTX01282-pro

Application

Functional Assay

Species

Human
Package
50 μg ($319),
20 μg ($229)

APPLICATION

Application Note

Measured by its binding ability in a functional ELISA. Immobilized human Renin-his protein (GTX01282-pro) at 10 μg/ml (100 μl/well) can bind biotinylated human AGT-his protein (GTX01232-pro) with a linear range of 0.156-5.0 μg/ml.

Observed MW

50 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal poly His tagged; Met1-Arg406 of Human Renin protein (NP_000528.1)

Expression System

HEK293 cells

Purity

> 95% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

HNFJ2

Background

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human Renin protein, His tag. GTX01282-pro

GTX01282-pro Image

SDS-PAGE of 5 μg GTX01282-pro Human Renin protein.

REFERENCE

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REVIEW

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Package List Price ($)
$ 319
$ 229