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United States (US)

Human SOD1 protein (active)

Cat. No. GTX04316-pro

Application

 Functional Assay

Species

 Human
Package
100 μg ($299)
See all SOD1 protein products

APPLICATION

Application Note

The potency per mg was tested by Pyrogallic Acid method and was found to be more than 3,000 Units/mg.

Observed MW

31.6 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with sterile H₂O but not less than 100 μg/ml. Lyophilized from 0.2μm filtered concentrated solution in PBS pH 7.4.

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1 week), store at 4ºC. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA), aliquot, and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Region/Sequence

ATKAVCVLKG DGPVQGIINF EQKESNGPVK VWGSIKGLTE GLHGFHVHEF GDNTAGCTSA GPHFNPLSRK HGGPKDEERH VGDLGNVTAD KDGVADVSIE DSVISLSGDH CIIGRTLVVH EKADDLGKGG NEESTKTGNA GSRLACGVIG IAQ

Expression System

E. coli

Purity

> 95 % by RP-HPLC and SDS-PAGE

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

superoxide dismutase 1 , ALS , ALS1 , HEL-S-44 , IPOA , SOD , hSod1 , homodimer

Cellular Localization

Cytoplasm , Mitochondrion , Nucleus

Background

The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 299