GeneTex
  • Country / Location Selection

United States (US)

Human TIMP1 protein, His tag (active)

Human TIMP1 protein, His tag (active). GTX01221-pro

Cat No. GTX01221-pro

Application

Functional Assay

Species

Human
Package
20 μg ($299),
10 μg ($219)

APPLICATION

Application Note

Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2. The IC₅₀ value is < 6 nM.

Observed MW

30 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal poly His tagged; Met1-Ala207 of Human TIMP1 protein (NP_003245.1)

Expression System

HEK293 cells

Purity

> 97% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CLGI,EPA,EPO,HCI,TIMP,TIMP-1

Background

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human TIMP1 protein, His tag (active). GTX01221-pro

GTX01221-pro Image

SDS-PAGE of 5 μg GTX01221-pro Human TIMP1 protein, His tag (active).

REFERENCE

There are currently no references for Human TIMP1 protein, His tag (active) (GTX01221-pro). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Human TIMP1 protein, His tag (active) (GTX01221-pro). Be the first to share your experience with this product.
Package List Price ($)
$ 299
$ 219