Form
Liquid
Buffer
PBS, 10% Glycerol, 1mM DTT
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Region/Sequence
Full length protein, N-terminal His-Tag; MGSSHHHHHH SSGLVPRGSH MGSEFMEFLL GNPFSTPVGQ CLEKATDGSL QSEDWTLNME ICDIINETEE GPKDAIRALK KRLNGNRNYR EVMLALTVLE TCVKNCGHRF HILVANRDFI DSVLVKIISP KNNPPTIVQD KVLALIQAWA DAFRSSPDLT GVVHIYEELK RKGVEFPMAD LDALSPIHTP QRSVPEVDPA ATMPRSQSQQ RTSAGSYSSP PPAPYSAPQA PALSVTGPIT ANSEQIARLR SELDVVRGNT KVMSEMLTEM VPGQEDSSDL ELLQELNRTC RAMQQRIVEL ISRVSNEEVT EELLHVNDDL NNVFLRYERF ERYRSGRSVQ NASNGVLNEV TEDNLIDLGP GSPAVVSPMV GNTAPPSSLS SQLAGLDLGT ESVSGTLSSL QQCNPRDGFD MFAQTRGNSL AEQRKTVTYE DPQAVGGLAS ALDNRKQSSE GIPVAQPSVM DDIEVWLRTD LKGDDLEEGV TSEEFDKFLE ERAKAAEMVP DLPSPPMEAP APASNPSGRK KPERSEDALF AL
Expression System
E. coli
Purity
> 80% by SDS-PAGE.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
target of myb1 like 2 membrane trafficking protein
Background
This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]
Database
Research Area