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Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils)

Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils). GTX17675-pro
Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils). GTX17675-pro
Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils). GTX17675-pro
Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils). GTX17675-pro

Cat No. GTX17675-pro

Application

 Functional Assay

Species

 Human
Package
200 μg ($509),
100 μg ($369)
See all Tau protein products

APPLICATION

Application Note

Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.

PROPERTIES

Form

Liquid

Buffer

10 mM HEPES, 100 mM NaCl pH 7.4

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Concentration

batch dependent (Please refer to the vial label for the specific concentration.)

Region/Sequence

Partial Tau without tagged; SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVLGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE

Expression System

E. coli

Purification

Purified by ion-exchange chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

microtubule associated protein tau , microtubule associated protein tau , DDPAC , FTDP-17 , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU

Database

  • Gene ID: 4137 MAPT

Research Area

DATA IMAGES

Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils). GTX17675-pro

GTX17675-pro Image

SDS-PAGE of ~15 kDa Human Tau (K18) protein, mutant P301L (active, preformed fibrils (PFFs)) (GTX17675-pro).
Lane 1: MW Ladder. Lane 2: Human Tau (K18) protein, mutant P301L (active, fibrils) (GTX17675-pro).

Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils). GTX17675-pro

GTX17675-pro Image

TEM of Human Tau (K18) protein, mutant P301L (active, preformed fibrils (PFFs)) at 30kx magnification. HV=80kV. Fibrils were sonicated and stained with uranyl acetate.

Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils). GTX17675-pro

GTX17675-pro Image

TEM of Human Tau (K18) protein, mutant P301L (active, preformed fibrils (PFFs)) at 150kx magnification. HV=80kV. Fibrils were sonicated and stained with uranyl acetate.

Human Tau (K18) protein, mutant P301L (active, Pre-formed Fibrils). GTX17675-pro

GTX17675-pro Image

Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau preformed fibrils (GTX17675-pro). Tau preformed fibrils (GTX17675-pro) seed the formation of new tau fibrils when combined with tau monomers (GTX17672-pro). Thioflavin T ex = 450 nm, em = 485 nm.

REFERENCE

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REVIEW

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Package List Price ($)
$ 509
$ 369