GeneTex
  • Country / Location Selection

United States (US)

Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils)

Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils). GTX17674-pro
Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils). GTX17674-pro
Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils). GTX17674-pro
Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils). GTX17674-pro

Cat No. GTX17674-pro

Application Functional Assay
Species Human
Package
200 μg ($509),
100 μg ($369)
APPLICATION

Application Note

Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
PROPERTIES

Form

Liquid

Buffer

10 mM HEPES, 100 mM NaCl pH 7.4

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Concentration

batch dependent (Please refer to the vial label for the specific concentration.)

Region/Sequence

Full-length without tagged; MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L

Expression System

E. coli

Purification

Purified by ion-exchange chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

microtubule associated protein tau , microtubule associated protein tau , DDPAC , FTDP-17 , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU

Database

  • Gene ID: 4137 MAPT

Research Area

DATA IMAGES
Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils). GTX17674-pro

GTX17674-pro Image

TEM of Human Tau441 (2N4R) protein, mutant P301S (active, preformed fibrils (PFFs)) at 150kx magnification. HV = 80kV. Fibrils were sonicated and stained with uranyl acetate.

Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils). GTX17674-pro

GTX17674-pro Image

Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) when tau preformed fibrils (GTX17674-pro) are combined with tau monomers (GTX17672-pro). The preformed fibrils seed the formation of new fibrils from a pool of monomers. Thioflavin T ex = 450 nm, em = 485 nm.

Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils). GTX17674-pro

GTX17674-pro Image

SDS-PAGE of ~67 kDa Human Tau441 (2N4R) protein, mutant P301S (active, preformed fibrils (PFFs)) (GTX17674-pro).
Lane 1: MW Ladder. Lane 2: Human Tau441 (2N4R) protein, mutant P301S (active, fibrils)(GTX17674-pro).

Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils). GTX17674-pro

GTX17674-pro Image

TEM of Human Tau441 (2N4R) protein, mutant P301S (active, preformed fibrils (PFFs)). Fibrils were sonicated and stained with uranyl acetate.

REFERENCE
There are currently no references for Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils) (GTX17674-pro). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Human Tau441 (2N4R) protein, mutant P301S (active, Pre-formed Fibrils) (GTX17674-pro). Be the first to share your experience with this product.
Package List Price ($)
$ 509
$ 369