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Human Tau441 (2N4R) protein, mutant P301S (Pre-formed Fibrils)

Human Tau441 (2N4R) protein, mutant P301S (Pre-formed Fibrils). GTX17674-pro
Human Tau441 (2N4R) protein, mutant P301S (Pre-formed Fibrils). GTX17674-pro

Cat. No. GTX17674-pro

Application

 Functional Assay

Species

 Human
Package
200 μg ($689),
100 μg ($439)
See all Tau protein products

APPLICATION

Application Note

Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
*For best results, sonicate immediately prior to use.

PROPERTIES

Form

Liquid

Buffer

10mM HEPES pH7.4, 100mM NaCl

Preservative

No preservative

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Region/Sequence

Full-length without tagged; MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L

Expression System

E. coli

Purification

Purified by ion-exchange chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

microtubule associated protein tau , microtubule associated protein tau , DDPAC , FTDP-17 , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU

Database

  • Gene ID: 4137 MAPT

Research Area

DATA IMAGES

Human Tau441 (2N4R) protein, mutant P301S (Pre-formed Fibrils). GTX17674-pro

GTX17674-pro Image

SDS-PAGE of ~67 kDa Human Tau441 (2N4R) protein, mutant P301S (preformed fibrils (PFFs)) (GTX17674-pro).
Lane 1: MW Ladder. Lane 2: Human Tau441 (2N4R) protein, mutant P301S (fibrils)(GTX17674-pro).

Human Tau441 (2N4R) protein, mutant P301S (Pre-formed Fibrils). GTX17674-pro

GTX17674-pro Image

Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) when tau preformed fibrils (GTX17674-pro) are combined with tau monomers (GTX17672-pro). The preformed fibrils seed the formation of new fibrils from a pool of monomers. Thioflavin T ex = 450 nm, em = 485 nm.

REFERENCE

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REVIEW

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Package List Price ($)
$ 689
$ 439