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Human p23 protein (active)

Human p23 protein (active). GTX00443-pro

Cat No. GTX00443-pro

Application Functional Assay
Species Human
Package
50 μg ($269)
APPLICATION

Application Note

4 μM p23 Protein, when added to 2 μM AHA1 Protein (Aha1)-activated HSP90 (2 μM; His-tagged HSP90 beta) in 33 mM HEPES (pH 7.2) with 30 mM NaCl, 5 mM MgCl₂, 1 mM DTT, 1.5 mM ATP in a 100 μl reaction at 37 ºC, eliminated all Aha1-mediated ATPase stimulation as well as intrinsic HSP90 ATPase activity. (This is an enzyme-linked ATP regeneration assay tracking loss of NADH absorbance at 340nm).

Observed MW

23 kDa.
PROPERTIES

Form

Liquid

Buffer

20 mM HEPES buffer (pH 7.2), 80 mM NaCl, 10% glycerol.

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Concentration

Batch dependent

Region/Sequence

Full-length protein; NP_006592.3 with N-terminal SH residue

Expression System

E. coli

Purification

Affinity Purified

Purity

> 90%

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

prostaglandin E synthase 3 , P23 , TEBP , cPGES

Background

This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES
Human p23 protein (active). GTX00443-pro

GTX00443-pro Image

SDS-PAGE analysis of GTX00443-pro Human p23 protein (active).

REFERENCE
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REVIEW
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Package List Price ($)
$ 269