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Human p53 protein, His tag

Human p53 protein, His tag. GTX04503-pro

Cat. No. GTX04503-pro

Species

 Human
Package
50 μg ($529)
See all p53 protein products

APPLICATION

Observed MW

57 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with ddH₂O to 0.1-0.2 mg/mL. Do not vortex. Lyophilized from 20mM Tris (pH8.0), 150mM NaCl, 0.01% SKL, 5% Trehalose.

Preservative

No preservatives

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Region/Sequence

N-terminal His tagged full length human p53 protein (Met1~Asp393, Uniprot #P04637-1)

Expression System

E. coli

Purity

>90%

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53

Cellular Localization

Cytoplasm , Nucleus , Endoplasmic reticulum , Mitochondrion matrix

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Database

Research Area

DATA IMAGES

Human p53 protein, His tag. GTX04503-pro

GTX04503-pro Image

SDS-PAGE analysis of GTX04503-pro Human p53 protein, His tag.

REFERENCE

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Package List Price ($)
$ 529