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IGF1R alpha + beta antibody [alphaIR3]

Cat. No. GTX16890

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 alphaIR3

Isotype

 IgG1

Application

 ICC/IF, IP, Neutralizing/Inhibition

Reactivity

 Human
Package
50 μg ($399)
See all IGF1R products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF 1 - 5 μg/ml
IP Assay dependent
Neutralizing/Inhibition 1 μg/ml
Not tested in other applications.

Calculated MW

155 kDa. ( Note )

Positive Control

HepG2 cells

Product Note

This antibody recognizes the ~130 kDa α and the ~90 kDa β subunits of IGF-I receptor and is not suitable for use in IHC-P or WB.

PROPERTIES

Form

Liquid

Buffer

0.05M Sodium Phosphate buffer, 0.2% Gelatin

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Immunogen used was partially purified receptor from human placenta.

Purification

Affinity purified with antigen

Conjugation

Unconjugated

RRID

AB_425129

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

insulin like growth factor 1 receptor , CD221 , IGFIR , IGFR , JTK13

Cellular Localization

Cell membrane

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

REFERENCE

Application Reference

Walz M et al. Cells 2021; 10 (3) Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices.
Higa-Nakamine S et al. J Cell Physiol 2012; 227 (6) : 2492-501 selective cleavage of erbb4 by g-protein-coupled *-releasing hormone receptor in cultured hypothalamic neurons.
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399