For IF: Use at a concentration of 1 - 5 μg/ml. For IP: Use at an assay dependent dilution. For Neut: Use at a concentration of 1 μg/ml. Not suitable for use in IHC-P or WB. Optimal dilutions/concentrations should be determined by the researcher.
Recognizes the human IGF-I Receptor. IGF-I Receptor (Ab-1) immunoprecipitates the a and ? subunits of the IGF-I receptor. IGF-I receptor (GTX16890) blocks IGF-I binding to its receptor and may bind weakly to the insulin receptor. It also inhibits the growth of MCF-7 cells in culture suggesting the IGF-I receptor may be involved in autocrine regulation of cell growth.
0.05 M sodium phosphate buffer, 0.2% gelatin, and =0.1% sodium azide.
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Immunogen used was partially purified receptor from human placenta.
Affinity purified with antigen
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Insulin Like Growth Factor 1 Receptor,Cd221,Igfir,Igfr,Jtk13,Igf1R
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]