*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
The antibody blocks cell surface IGF-I R mediated IGF-I and IGF-II biological activity. At optimal antibody concentration, no more than 40-60% of the IGF-I or IGF-II activity can be blocked by this antibody.
PBS, 5% trehalose
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Batch dependent (Please refer to the vial label for the specific concentration.)
Recombinant human IGF-I soluble receptor expressed in Sf 21.
Purified by affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
insulin like growth factor 1 receptor , CD221 , IGFIR , IGFR , JTK13
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]