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United States (US)

IGF1R antibody

Cat No. GTX10729

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB, ELISA, Neut
Reactivity Human
Package
25 μg ($319)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ELISA Assay dependent
Neut Assay dependent
Not tested in other applications.

Calculated MW

155 kDa. ( Note )

Specificity/Sensitivity

The antibody blocks cell surface IGF-I R mediated IGF-I and IGF-II biological activity. At optimal antibody concentration, no more than 40-60% of the IGF-I or IGF-II activity can be blocked by this antibody.
PROPERTIES

Form

Liquid

Buffer

PBS, 5% trehalose

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human IGF-I soluble receptor expressed in Sf 21.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Insulin Like Growth Factor 1 Receptor,Cd221,Igfir,Igfr,Jtk13,Igf1R

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

REFERENCE
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REVIEW
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Package List Price ($)
$ 319