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IGF1R antibody

Anti-IGF1R antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50433
Anti-IGF1R antibody used in Western Blot (WB). GTX50433
Anti-IGF1R antibody used in IHC (Paraffin sections) (IHC-P). GTX50433

Cat No. GTX50433

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:1000
ICC/IF 1:100-1:200
IHC-P 1:50-1:100
Not tested in other applications.

Calculated MW

155 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH 7.4, 150mM NaCl, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide sequence around aa.1159~1163 (D-I-Y-E-T) derived from human IGF1R.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

insulin like growth factor 1 receptor , CD221 , IGFIR , IGFR , JTK13

Cellular Localization

Cell membrane

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

DATA IMAGES

Anti-IGF1R antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50433

GTX50433 ICC/IF Image

ICC/IF analysis of methanol-fixed MCF cells using GTX50433 IGF1R antibody.

Anti-IGF1R antibody used in Western Blot (WB). GTX50433

GTX50433 WB Image

WB analysis of extracts from 293 cells using GTX50433 IGF1R antibody with or without blocking peptide.

Anti-IGF1R antibody used in IHC (Paraffin sections) (IHC-P). GTX50433

GTX50433 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX50433 IGF1R antibody.
Left : Primary antibody
Right : Primary antibody pre-incubated with the antigen specific peptide

REFERENCE

REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319