IGF1R beta (phospho Tyr950) antibody

Cat. No. GTX79047

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	IHC-P
Reactivity	Human
Package	100 μg ($399)

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Datasheet

View product citations for antibody GTX79047 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
IHC-P	1:50 - 1:100

Not tested in other applications.

Calculated MW

155 kDa. ( Note )

Product Note

The full-length IGF1R includes the 30 aa signal peptide that is cleaved during maturation. The Tyr950 of mature IGF1R is equivalent to Tyr980 of uncleaved IGF1R.

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human IGF1R around the phosphorylation site of tyrosine 980 (P-E-Yp-F-S ).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

RRID

AB_11166891

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD221,IGF1R,IGFIR,IGFR,JTK13,insulin like growth factor 1 receptor,IGF1R alpha,IGF1R beta,IGF1 Receptor alpha,IGF1 Receptor beta

Cellular Localization

Cell membrane

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Gene ID: 3480 IGF1R
UniProt: P08069 IGF1R

Research Area

DATA IMAGES

GTX79047 IHC-P Image

IHC-P analysis of human lung adenocarcinoma tissue using GTX79047 IGF1R beta (phospho Tyr950) antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 399

Qty