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IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody

Anti-IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody used in IHC (Paraffin sections) (IHC-P). GTX79046
Anti-IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody used in Western Blot (WB). GTX79046

Cat No. GTX79046

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μg ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

155 kDa. ( Note )

Product Note

This antibody is raised against a synthetic peptide around phosphorylated Tyr1131 of IGF1R (signal peptide cleaved form), which is identical to the sequence around phosphorylated Tyr1146 of Insulin Receptor (signal peptide cleaved form of P06213-2).

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human IGF-1R around the phosphorylation site of tyrosine 1161 (D-I-Yp-E-T).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

RRID

AB_11173334

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD221,IGF1R,IGFIR,IGFR,JTK13,insulin like growth factor 1 receptor,IGF1R alpha,IGF1R beta,IGF1 Receptor alpha,IGF1 Receptor beta

Cellular Localization

Cell membrane

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

DATA IMAGES

Anti-IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody used in IHC (Paraffin sections) (IHC-P). GTX79046

GTX79046 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX79046 IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody.

Anti-IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody used in Western Blot (WB). GTX79046

GTX79046 WB Image

WB analysis of 293 cells untreated (left) or treated(right) with Insulin using GTX79046 IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody.

REFERENCE

There are currently no references for IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody (GTX79046). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for IGF1R (phospho Tyr1131) / Insulin Receptor (phospho Tyr1146) antibody (GTX79046). Be the first to share your experience with this product.
Package List Price ($)
$ 379