IGF1R beta (phospho Tyr1131) / Insulin Receptor beta (phospho Tyr1146) antibody

Cat. No. GTX79046

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human
Package	100 μg ($399)

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Datasheet

View product citations for antibody GTX79046 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500 - 1:1000
IHC-P	1:50 - 1:100

Not tested in other applications.

Calculated MW

155 kDa. ( Note )

Product Note

Tyr1161 in full-length IGF-1R is equivalent toTyr1131 in signal peptide cleaved IGF1R, and Tyr1185 in full-length Insulin Receptor is equivalent to Tyr1146 in signal peptide cleaved Insulin Receptor.

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human IGF-1R around the phosphorylation site of tyrosine 1161 (D-I-Yp-E-T), which is equivalent to Tyrosine 1131 in signal peptide cleaved IGF1R.

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

RRID

AB_11173334

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD221,IGF1R,IGFIR,IGFR,JTK13,insulin like growth factor 1 receptor,IGF1R alpha,IGF1R beta,IGF1 Receptor alpha,IGF1 Receptor beta

Cellular Localization

Cell membrane

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Gene ID: 3480 IGF1R
UniProt: P08069 IGF1R

Research Area

DATA IMAGES

GTX79046 WB Image

WB analysis of 293 cells untreated (left) or treated(right) with Insulin using GTX79046 IGF1R beta (phospho Tyr1131) / Insulin Receptor beta (phospho Tyr1146) antibody.

GTX79046 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX79046 IGF1R beta (phospho Tyr1131) / Insulin Receptor beta (phospho Tyr1146) antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 399

Qty