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IGF1R (phospho Tyr1250) antibody

Anti-IGF1R (phospho Tyr1250) antibody used in Western Blot (WB). GTX50683

Cat No. GTX50683

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:1000
Not tested in other applications.

Calculated MW

155 kDa. ( Note )

Specificity/Sensitivity

The full-length IGF1R includes the 30 aa signal peptide that is cleaved during maturation. The Tyr1250 of mature IGF1R is equivalent toTyr1280 of uncleaved IGF1R.

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH 7.4, 150mM NaCl, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide sequence around phosphorylation site of tyrosine 1250 (S-F-Y(p)-Y-S) derived from human IGF1R.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

insulin like growth factor 1 receptor , CD221 , IGFIR , IGFR , JTK13

Cellular Localization

Cell membrane

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

DATA IMAGES

Anti-IGF1R (phospho Tyr1250) antibody used in Western Blot (WB). GTX50683

GTX50683 WB Image

WB analysis of extracts from 293 cells treated with insulin using GTX50683 IGF1R (phospho Tyr1250) antibody.

REFERENCE

There are currently no references for IGF1R (phospho Tyr1250) antibody (GTX50683). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for IGF1R (phospho Tyr1250) antibody (GTX50683). Be the first to share your experience with this product.
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319