*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
IGF-1 treated MCF-7 cell
The full-length IGF1R includes the 30 aa signal peptide that is cleaved during maturation. The Tyr1316 of mature IGF1R is equivalent toTyr1346 of uncleaved IGF1R.
Bovine, Pig, Xenopus laevis, Rhesus Monkey(>80% identity)
1XPBS (pH7), 1% BSA, 20% Glycerol
0.025% ProClin 300
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
4 mg/ml (Please refer to the vial label for the specific concentration.)
Carrier-protein conjugated synthetic peptide surrounding phospho Tyr1316 of human IGF1R. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
insulin like growth factor 1 receptor , CD221 , IGFIR , IGFR , JTK13
Membrane; Single-pass type I membrane protein
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq]