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IGF2R antibody [MEM-238]

Anti-IGF2R antibody [MEM-238] used in Western Blot (WB). GTX28093

Cat. No. GTX28093

Reference 4

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MEM-238

Isotype

 IgG1

Application

 WB, FACS, IP

Reactivity

 Human, Mouse, Primate
Package
100 μg ($399)
See all IGF2R products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
FACS Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

274 kDa. ( Note )

Product Note

This antibody recognizes an epitope between amino acids 192-697 of CD222 (IGF2 receptor).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant Vaccinia virus encoding CD222.

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_368984

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD222 , CIM6PR , CIMPR , IGF2R , M6P/IGF2R , M6PR , MPR 300 , MPR1 , MPR300 , MPRI , insulin like growth factor 2 receptor , IGF2 receptor , cation-independent M6PR , IGF-IIR

Cellular Localization

Lysosome membrane

Background

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]

Database

Research Area

DATA IMAGES

Anti-IGF2R antibody [MEM-238] used in Western Blot (WB). GTX28093

GTX28093 WB Image

Fig. 1. Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line.
Lane 1: immunostaining with anti-CD222 [MEM-238]
Lane 2: immunostaining with Isotype mouse IgG1 control

REFERENCE

Application Reference

K?seo?lu HG et al. BMC Dermatol 2020; 20 (1) : 14 The role of insulin-like growth factor in Acrochordon Etiopathology.
Koeberl DD et al. FASEB J 2014; 28 (5) : 99134 Adjunctive * enhances the response to enzyme replacement therapy in late-onset Pompe disease.
Li S et al. FASEB J 2013; 27 (1) : 34-44 Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease.
Application : WB
Reactivity : Mouse
Koeberl DD et al. Mol Genet Metab 2011; 103 (2) : 107-12 Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle.
Application : WB
Reactivity : Mouse
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399