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IGF2R antibody

Anti-IGF2R antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX12397
Anti-IGF2R antibody used in IHC (Paraffin sections) (IHC-P). GTX12397
Anti-IGF2R antibody used in Western Blot (WB). GTX12397

Cat No. GTX12397

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P

Reactivity

Human, Mouse, Rat
Package
100 μg ($349)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.1-0.5μg/ml
ICC/IF 0.5-1μg/ml
IHC-P 0.5-1μg/ml
Not tested in other applications.

Calculated MW

274.38 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

2.5% BSA, 0.45% NaCl, 0.1% Na₂HPO₄, 0.025% Thimerosal, 0.025% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

500 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Mannose 6 Phosphate Receptor(Cation independent)(2475-2491aa TKLVSFHDDSDEDLLHI), different from the related rat and mouse sequences by one amino acid.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Cellular Localization

Lysosome membrane

Background

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]

Database

Research Area

DATA IMAGES

Anti-IGF2R antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX12397

GTX12397 ICC/IF Image

ICC/IF analysis of HCT116 cell using GTX12397 IGF2R antibody.

Anti-IGF2R antibody used in IHC (Paraffin sections) (IHC-P). GTX12397

GTX12397 IHC-P Image

IHC-P analysis of human intestinal cancer tissue using GTX12397 IGF2R antibody.

Anti-IGF2R antibody used in Western Blot (WB). GTX12397

GTX12397 WB Image

WB analysis of various samples using GTX12397 IGF2R antibody.
Lane 1 : HeLa whole cell lysate at 40ug
Lane 2 : Jurkat whole cell lysate at 40ug
Lane 3 : 22RV1 whole cell lysate at 40ug
Lane 4 : 293T whole cell lysate at 40ug
Dilution : 0.5 μg/mL

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Thimerosal.pdf
Package List Price ($)
$ 349