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IKK alpha (phospho Ser176) + IKK beta (phospho Ser177) antibody

Anti-IKK alpha (phospho Ser176) + IKK beta (phospho Ser177) antibody used in Western Blot (WB). GTX52310

Cat. No. GTX52310

Reference 3

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all IKK alpha products

APPLICATION

Application Note

WB 1:500-1:2000, IHC 1:50-1:200

Calculated MW

85 kDa. ( Note )

Product Note

CHUK

PROPERTIES

Form

Liquid

Buffer

PBS, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthesized peptide derived from human IKK- beta around the phosphorylation site of Ser177

Purification

Antigen affinity purification

Conjugation

Unconjugated

RRID

AB_2887788

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

component of inhibitor of nuclear factor kappa B kinase complex , IKBKA , IKK-alpha , IKK1 , IKKA , NFKBIKA , TCF16

Cellular Localization

Cytoplasm , Nucleus

Background

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-IKK alpha (phospho Ser176) + IKK beta (phospho Ser177) antibody used in Western Blot (WB). GTX52310

GTX52310 WB Image

Western blot analysis of IKK- alpha /IKK- beta phosphorylation expression in TNF treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

REFERENCE

Application Reference

Mora-Ramiro B et al. J Nat Prod 2020; 83 (8) : 2447-2455 Cacalol Acetate, a Sesquiterpene from Psacalium decompositum, Exerts an Anti-inflammatory Effect through LPS/NF-KB Signaling in Raw 264.7 Macrophages.
Application : WB
Reactivity : Mouse
Chao CC et al. Cancers (Basel) 2020; 12 (2) CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in Osteosarcoma.
Application : WB
Reactivity : Human
Gao F et al. Adv Sci (Weinh) 2019; 6 (7) : 1801671 Au Clusters Treat Rheumatoid Arthritis with Uniquely Reversing Cartilage/Bone Destruction.
Submit a Reference

REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399