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United States (US)

IKK gamma peptide

Cat. No. GTX27896

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($139)
See all IKK gamma products

APPLICATION

Application Note

The peptide is used for blocking the antibody activity of IKKg (GTX27890). Itusually blocks the antibody activity completely in Western blot by incubating the peptide withequal volume of antibody for 30 min at 37ºC

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Gamma , Amcbx1 , Fip-3 , Fip3 , Fip3P , Ikk-Gamma , Ikkap1 , Ikkg , Imd33 , Ip , Ip1 , Ip2 , Ipd2 , Nemo , Zc2Hc9 , Ikbkg

Cellular Localization

Cytoplasmic and Nuclear

Background

Pro inflammatory cytokines activate the transcription factor NF kappa B by stimulating the activity of a protein kinase that phosphorylates Ikappa B, an inhibitor of NF kappa B, at sites that trigger its ubiquitination and degradation. A large, cytokine responsive Ikappa B kinase (IKK) complex has been purified and the genes encoding 2 of its subunits have been cloned. These subunits, IKK alpha and Ikk beta, are protein kinases whose function is needed for NF kappa B activation by pro inflammatory stimuli. IKK is composed of similar amounts of IKK alpha, Ikk beta, which are differentially processed forms of a third subunit, IKK gamma. Ikk gamma interacts preferentially with IKK beta and is required for the activation of the IKK complex.

Research Area

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139