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IL1 Receptor 1 antibody

Cat. No. GTX22575

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, FACS, IP, ELISA, IHC, Neutralizing/Inhibition

Reactivity

 Human, Primate
Package
500 μl ($739)
See all IL1 Receptor 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
FACS Assay dependent
IP Assay dependent
ELISA Assay dependent
IHC Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

65 kDa. ( Note )

Product Note

The antiserum is directed against the extracellular domain of the human IL-1R type I, but precipitates the intact receptor expressed on human cells. The antibody does not recognize human IL-1, IL-1Ra or IL-1R type II. In ELISA formats and other immunoreactive assays, this antibody will detect the extracellular domain of the IL-1R type I (also called soluble IL-1R type I or ''decoy'' receptor) found in human body fluids, particularly in the circulation, urine and supernatants of cells and synovial fluid.

PROPERTIES

Form

Liquid

Buffer

10mM Sodium Phosphate, 150mM NaCl

Preservative

0.01% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

84 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human IL-1R type I.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interleukin 1 receptor type 1 , CD121A , D2S1473 , IL-1R-alpha , IL1R , IL1RA , P80

Cellular Localization

Membrane,Cell membrane,Secreted

Background

Interleukin 1 (IL-1), which has a role as a mediator in inflammation, actually consists of 2 separate but related proteins, IL-1 alpha and IL-1 beta. Cell surface receptors for the 2 forms of IL-1 are identical. IL-1R Type I contains a single membrane-spanning segment, a large cytoplasmic region, and an extracellular, IL-1 binding portion composed of 3 immunoglobulin-like domains.

Database

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 739