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IL1 beta antibody

Orthogonal
Anti-IL1 beta antibody used in IHC (Paraffin sections) (IHC-P). GTX74034
Anti-IL1 beta antibody used in Western Blot (WB). GTX74034
Anti-IL1 beta antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX74034
Anti-IL1 beta antibody used in IHC (Frozen sections) (IHC-Fr). GTX74034
Anti-IL1 beta antibody used in ELISA (ELISA). GTX74034
Anti-IL1 beta antibody used in Western Blot (WB). GTX74034
Anti-IL1 beta antibody used in Western Blot (WB). GTX74034
Anti-IL1 beta antibody used in Western Blot (WB). GTX74034
Anti-IL1 beta antibody used in Western Blot (WB). GTX74034
Anti-IL1 beta antibody used in Western Blot (WB). GTX74034
Anti-IL1 beta antibody used in Western Blot (WB). GTX74034

Cat. No. GTX74034

Reference 100
1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, ELISA, IHC

Reactivity

 Human, Mouse, Rat
Package
100 μl ($469)
See all IL1 beta products
PRODUCT

Summary

Interleukin-1 beta (IL-1 beta) antibody detects IL-1 beta protein, which is a proinflammatory cytokine produced by active macrophages. In recent reports, IL-1 beta activation via caspase-1 can be induced by infectious pathogens in a process known as “pyroptosis”, a form of programmed cell death that initiates an inflammatory antimicrobial response. IL-1 beta is also a key factor in cytokine storms associated with both infectious and non-infectious diseases.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Fr 1:100-1:1000
ELISA 0.5-2μg/ml
IHC Assay dependent
Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Positive Control

Raw264.7 (500ng/ml LPS treatment for 6 hr)

Predict Reactivity

Mouse (100%)| Rat (90%)| Rabbit (81%)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Recombinant murine IL1 beta

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_378141

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interleukin 1 beta , IL-1beta , Il-1b

Database

Research Area

DATA IMAGES

Anti-IL1 beta antibody used in IHC (Paraffin sections) (IHC-P). GTX74034

GTX74034 IHC-P Image

IL1 beta antibody detects IL1 beta protein at microglia by immunohistochemical analysis.
Sample: Paraffin-embedded rat cerebellum.
Green: IL1 beta stained by IL1 beta antibody (GTX74034) diluted at 1:250.
Red: NF-H, a neuron marker, stained by NF-H antibody [GT114] (GTX634289) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-IL1 beta antibody used in Western Blot (WB). GTX74034

GTX74034 WB Image

Orthogonal

Untreated (–) and treated (+) THP-1 whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with IL1 beta antibody (GTX74034) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-IL1 beta antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX74034

GTX74034 ICC/IF Image

IL1 beta antibody detects IL1 beta protein by immunofluorescent analysis.
Sample: DIV9 rat E18 primary cortical neuron and glia cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: IL1 beta stained by IL1 beta antibody (GTX74034) diluted at 1:500.
Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody [GT11710] (GTX631836) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).

Anti-IL1 beta antibody used in IHC (Frozen sections) (IHC-Fr). GTX74034

GTX74034 IHC-Fr Image

IL1 beta antibody detects IL1 beta protein at microglia by immunohistochemical analysis.
Sample: Frozen-sectioned mouse hippocampus.
Green: IL1 beta stained by IL1 beta antibody (GTX74034) diluted at 1:250.
Blue: Fluoroshield with DAPI (GTX30920).

Anti-IL1 beta antibody used in ELISA (ELISA). GTX74034

GTX74034 ELISA Image

An ELISA plate is coated with 50 μL of IL1 beta recombinant protein at concentration of 5 μg/mL. The coated protein is detected with anti-IL1 beta antibody (GTX74034) at concentration ranged from 0.01 to 0.15 μg/mL.

Anti-IL1 beta antibody used in Western Blot (WB). GTX74034

GTX74034 WB Image

Orthogonal

Untreated (–) and treated (+) Raw264.7 whole cell extract (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with IL1 beta antibody (GTX74034) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-IL1 beta antibody used in Western Blot (WB). GTX74034

GTX74034 WB Image

Orthogonal

The data was published in the 2022 in Sci Rep. PMID: 35256715

Anti-IL1 beta antibody used in Western Blot (WB). GTX74034

GTX74034 WB Image

Orthogonal

The data was published in the 2019 in Commun Biol. PMID: 31602405

Anti-IL1 beta antibody used in Western Blot (WB). GTX74034

GTX74034 WB Image

Orthogonal

The data was published in the journal Nat Commun in 2015.PMID: 26104484

Anti-IL1 beta antibody used in Western Blot (WB). GTX74034

GTX74034 WB Image

Orthogonal

The data was published in the 2022 in Sci Rep. PMID: 35256715

Anti-IL1 beta antibody used in Western Blot (WB). GTX74034

GTX74034 WB Image

The data was published in the 2022 in Sci Rep. PMID: 35256715

REFERENCE

Application Reference

Govindappa PK et al. Res Sq 2024; 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury.
Joshi R et al. J Neuroinflammation 2024; 21 (1) : 212 IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.
H Wang et al. Sci Rep 2024; 14 (1) : 20092 Crisaborole combined with vitamin D demonstrates superior therapeutic efficacy over either monotherapy in mice with allergic contact dermatitis
PK Govindappa et al. Research Square 2024; 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury
Babuta M et al. Cells 2024; 13 (11) Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver.
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REVIEW

IL1 beta antibody Cat. No. GTX74034

Rating
( Average 5 based on 1 users reviews)
Application
Western Blot(WB)
( Average 5 based on 1 users reviews)
Anti-IL1 beta antibody used in Western Blot (WB). GTX74034
Date : Anonymous submitted on 13-Mar-2015
Score :
Application Tested : WB
Sample Species : Ms
Sample : skin tissue
Amount used : 30μg
Blocking : 5% non-fat milk, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Submit a Review
Application Reference
Govindappa PK et al. Res Sq 2024; 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury.
Joshi R et al. J Neuroinflammation 2024; 21 (1):212 IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.
H Wang et al. Sci Rep 2024; 14 (1):20092 Crisaborole combined with vitamin D demonstrates superior therapeutic efficacy over either monotherapy in mice with allergic contact dermatitis
PK Govindappa et al. Research Square 2024; 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury
Babuta M et al. Cells 2024; 13 (11) Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver.
Vande Walle L et al. Life Sci Alliance 2024; 7 (6) Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency.
Application : WB
Hartmann J et al. Nat Commun 2024; 15 (1):2635 SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Gao W et al. BMC Cardiovasc Disord 2024; 24 (1):82 Mycn ameliorates cardiac hypertrophy-induced heart failure in mice by mediating the USP2/JUP/Akt/β-catenin cascade.
Daily KP et al. Alzheimers Res Ther 2024; 16 (1):29 DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.
X Yu et al. Nat Commun 2024; 15 (1):1164 Structural basis for the oligomerization-facilitated NLRP3 activation
Ma L et al. iScience 2023; 26 (12):108463 Gasdermin D promotes hyperuricemia-induced renal tubular injury through RIG-I/caspase-1 pathway.
S Ryu et al. J Clin Invest 2023; Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity
Cui J et al. bioRxiv 2023; Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation.
Pourcelot M et al. Pathogens 2023; 12 (6) Activation of Inflammasome during Bluetongue Virus Infection.
Chen SH et al. Front Neurosci 2023; 17:1172740 Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerve.
JL Yeh et al. Biomed Pharmacother 2023; 165:115109 Xanthine derivative KMUP-1 ameliorates retinopathy
Application : WB, IHC
Reactivity : Mouse
PY Liu et al. Cell Death Dis 2023; 14 (6):369 RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury
Application : WB
Marie Pourcelot et al. Pathogens 2023; 12 (6):801 Activation of Inflammasome during Bluetongue Virus Infection
Application : WB
Reactivity : Mouse
Eeckhout E et al. Cell Death Dis 2023; 14 (4):282 Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection.
Application : WB
Reactivity : Mouse
Xia M et al. Neuroreport 2023; 34 (2):81-92 Knockout of transient receptor potential ankyrin 1 (TRPA1) modulates the glial phenotype and alleviates perihematomal neuroinflammation after intracerebral hemorrhage in mice via MAPK/NF-κB signaling.
Goldberg EL et al. J Biol Chem 2023; 299 (3):103005 Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation.
Application : WB
Reactivity : Mouse
Nomura M et al. bioRxiv 2023; A ketogenic diet reduces age-induced chronic neuroinflammation in mice Running title: ketogenic diet and brain inflammaging.
Pandeya A et al. Microbiol Res 2023; 275:127460 Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection.
Eeckhout E et al. Front Immunol 2023; 14:1272639 The autoinflammation-associated NLRC4(V341A) mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice.
Ryu S et al. Immunity 2022; 55 (9):1609-1626.e7 The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging.
Chauhan D et al. EMBO Rep 2022; 23 (10):e54277 GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis.
Vernon M et al. Mol Cancer Res 2022; 20 (12):1811-1821 Raptinal Induces Gasdermin E-Dependent Pyroptosis in Na?ve and Therapy-Resistant Melanoma.
Borges JP et al. Elife 2022; 11 Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Application : WB
Reactivity : Mouse
Devant P et al. STAR Protoc 2022; 3 (4):101848 Protocol to purify recombinant inflammatory caspases and assess their catalytic activity in?vitro.
Gros M et al. Cell Rep 2022; 40 (7):111205 Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation.
Mostafa M Eltobgy et al. Proc Natl Acad Sci U S A 2022; 119 (21):e2202012119 Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.
Application : IHC-Fr
Reactivity : Mouse
Rui Ding et al. J Neuroinflammation 2022; 19 (1):137 Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis.
Application : WB, IHC-P
Reactivity : Mouse
Lee SH et al. Sci Rep 2022; 12 (1):3681 Povidone iodine suppresses LPS-induced inflammation by inhibiting TLR4/MyD88 formation in airway epithelial cells.
Application : WB
Reactivity : Human
Evavold CL et al. Cell 2021; 184 (17):4495-4511.e19 Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.
Application : WB
Reactivity : Human
Xinbo Zhang et al. Proc Natl Acad Sci U S A 2021; 118 (47) Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.
Application : WB
Reactivity : Mouse
Oc?ane Dufies et al. Nat Microbiol 2021; 6 (3):401-412 Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice.
Application : WB
Reactivity : Human
Szu-Han Chen et al. Int J Mol Sci 2021; 22 (9) Investigation of Neuropathology after Nerve Release in Chronic Constriction Injury of Rat Sciatic Nerve.
Application : IHC-P
Reactivity : Rat
Seungjin Ryu et al. Elife 2021; 10 Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice.
Application : WB
Reactivity : Mouse
Yan Zhang et al. Blood Adv 2021; 5 (12):2619-2623 Inflammasome activation promotes venous thrombosis through pyroptosis.
Application : WB
Reactivity : Mouse
Lee KT et al. Aging (Albany NY) 2021; 13 (18):22490-22501 Nesfatin-1 facilitates IL-1β production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-κB pathways.
Application : WB
Reactivity : Human
Li H et al. J Inflamm Res 2021; 14:4839-4858 Neutrophil Extracellular Traps Augmented Alveolar Macrophage Pyroptosis via AIM2 Inflammasome Activation in LPS-Induced ALI/ARDS.
Application : WB
Su C.H. et al. Journal of Functional Foods 2021; 86 Betulin suppresses TNF-α and IL-1β production in osteoarthritis synovial fibroblasts by inhibiting the MEK/ERK/NF-κB pathway.
Application : WB, IHC-P
Reactivity : Human
Mayes-Hopfinger L et al. Nat Commun 2021; 12 (1):4546 Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.
Reactivity : Mouse
Jamieson S et al. Sci Rep 2021; 11 (1):10531 Inflammatory responses to metal oxide ceramic nanopowders.
Application : WB
Reactivity : Human
Guan C et al. Theranostics 2021; 11 (8):3981-3995 SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
Application : WB
Reactivity : Mouse
Xingyan Li et al. Nat Commun 2020; 11 (1):6364 Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners.
Application : WB
Reactivity : Human
Liu J et al. Front Pharmacol 2020; 11:812 Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production.
Hou B et al. Cell Death Dis 2020; 11 (5):377 Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype.
Fuster JJ et al. Cell Rep 2020; 33 (4):108326 TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.
Application : WB
Reactivity : Mouse
Fann DY et al. Neuromolecular Med 2020; 22 (4):474-483 CD137 Ligand-CD137 Interaction is Required For Inflammasome-Associated Brain Injury Following Ischemic Stroke.
Application : WB
Reactivity : Mouse
Zhou Y et al. Oncol Lett 2020; 20 (6):298 Anti-CD206 antibody-conjugated Fe3O4-based PLGA nanoparticles selectively promote tumor-associated macrophages to polarize to the pro-inflammatory subtype.
Application : WB
Reactivity : Mouse
Shi Y et al. J Cell Mol Med 2020; 24 (19):11397-11408 Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress.
Application : WB
Reactivity : Rat
Chang JW et al. Cereb Cortex 2020; 30 (8):4597-4606 Ultrasound Stimulation Suppresses LPS-Induced Proinflammatory Responses by Regulating NF-κB and CREB Activation in Microglial Cells.
Application : WB
Reactivity : Rat
Donado CA et al. Cell Rep 2020; 31 (1):107466 A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Application : WB
Reactivity : Mouse
Martins F et al. Cancers (Basel) 2020; 12 (4) Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer.
Application : WB
Reactivity : Human
Govindappa PK et al. Int Immunopharmacol 2020; 82:106330 An effective erythropoietin dose regimen protects against severe nerve injury-induced pathophysiological changes with improved neural gene expression and enhances functional recovery.
Application : IHC-P
Reactivity : Mouse
Qinyang Wang et al. Nature 2020; (Epub) A bioorthogonal system reveals antitumour immune function of pyroptosis.
Application : WB
Reactivity : Mouse
Wu C et al. Immunity 2019; 50 (6):1401-1411.e4 Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis.
Ising C et al. Nature 2019; 575 (7784):669-673 NLRP3 inflammasome activation drives tau pathology.
Application : WB
Reactivity : Human, Mouse
de Vasconcelos NM et al. Life Sci Alliance 2019; 2 (1) DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages.
Mamantopoulos M et al. Front Immunol 2019; 10:2463 El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes.
Application : WB
Reactivity : Mouse
Vande Walle L et al. PLoS Biol 2019; 17 (9):e3000354 MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
Application : WB
Reactivity : Human
Wei L et al. Brain Res 2019;:146423 Complement C3 participates in the function and mechanism of traumatic brain injury at simulated high altitude.
Application : IHC-P
Reactivity : Rat
Reitz CJ et al. Commun Biol 2019; 2:353 SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome.
Application : WB
Reactivity : Mouse
Lieselotte Vande Walle et al. bioRxiv 2019; (Epub) MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition.
Application : WB
Reactivity : Mouse
Han CJ et al. Acta Pharmacol Sin 2019; (Epub) The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway.
Application : WB
Reactivity : Mouse
Dubois H et al. PLoS Pathog 2019; 15 (4):e1007709 Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.
Application : WB
Reactivity : Mouse
Ji Y et al. Front Pharmacol 2019; 10:142 Vildagliptin Reduces Stenosis of Injured Carotid Artery in Diabetic Mouse Through Inhibiting Vascular Smooth Muscle Cell Proliferation via ER Stress/NF-κB Pathway.
Application : WB
Reactivity : Mouse
D'Eliseo D et al. J Ethnopharmacol 2019; 233:41-46 In vitro studies on anti-inflammatory activities of kiwifruit peel extract in human THP-1 monocytes.
Application : WB
Reactivity : Human
Kanneganti A et al. J Exp Med 2018; 215 (6):1519-1529 GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever.
Ravussin A et al. Cell Rep 2018; 24 (5):1085-1092.e6 Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.
Hafner-Bratkovi? I et al. Nat Commun 2018; 9 (1):5182 NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway.
Application : WB
Reactivity : Mouse
Skinner SC et al. Diabetes Care 2018; 41 (12):2595-2602 Increased Prevalence of Type 2 Diabetes-Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait.
Application : ELISA
Reactivity : Human
Pei-Ying Li et al. RSC Adv. 2018; 8:31515-31528 Alpinumisoflavone attenuates lipopolysaccharide-induced acute lung injury by regulating the effects of anti-oxidation and anti-inflammation both in vitro and.
Application : WB
Reactivity : Mouse
Zhou Y et al. Cancer Med 2018; (Epub) Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway.
Application : WB
Reactivity : Mouse
Singh AK et al. Sci Rep 2018; 8 (1):5932 Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals.
Lee BL et al. Sci Rep 2018; 8 (1):3788 ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages.
Reactivity : Mouse
Van Opdenbosch N et al. Cell Rep 2017; 21 (12):3427-3444 Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.
Application : WB
Reactivity : Mouse
Evavold CL et al. Immunity 2017; (Epub) The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.
Application : WB
Yang X et al. Cell Res 2017; (Epub) Structural basis for specific flagellin recognition by the NLR protein NAIP5.
Application : WB
Reactivity : Human
Mishra SK et al. Autophagy 2017;:1-46 CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation.
Kader M et al. PLoS Pathog 2017; 13 (10):e1006644 MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock.
Application : WB
Reactivity : Mouse
Zanoni I et al. Immunity 2017; 47 (4):697-709.e3 By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation.
Application : WB
Reactivity : Mouse
Chen YC et al. J Formos Med Assoc 2017; Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement.
Application : WB
Reactivity : Human
Kuo CY et al. Cancer Res 2017; (Epub) VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress-activated IRE1α signaling.
Application : WB
Reactivity : Human
Fuster JJ et al. Science 2017; 355 (6327):842-847 Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.
Application : WB
Reactivity : Mouse
Hassane M et al. Mucosal Immunol 2017; (Epub) Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections.
Application : WB
Reactivity : Mouse
Spadaro O et al. Cell Rep 2016; 14 (7):1571-1580 Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.
Van Gorp H et al. Proc Natl Acad Sci U S A 2016; 113 (50):14384-14389 Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.
Application : WB
Reactivity : Mouse
Zanoni I et al. Science 2016; 352 (6290):1232-6 An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells.
Application : ELISA
Reactivity : Mouse
Qu Y et al. J Exp Med 2016; (Epub) NLRP3 recruitment by NLRC4 during Salmonella infection.
Application : WB
Reactivity : Mouse
Camell CD et al. J Biol Chem 2015; 290 (49):29402-13 macrophage-specific de novo synthesis of ceramide is dispensable for inflammasome-driven inflammation and * resistance in obesity.
Application : WB
Reactivity : Mouse
Patankar YR et al. Am J Physiol Lung Cell Mol Physiol 2015; 309 (8):L902-13 Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1β response to Pseudomonas aeruginosa.
Kang S et al. Nat Commun 2015; 6 (Epub):7515 Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
Application : WB
Reactivity : Mouse
Youm YH et al. Nat Med 2015; 21 (3):263-9 The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Application : WB
Reactivity : Mouse
Van Opdenbosch N et al. Nat Commun 2014; 5:3209 Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Torres IM et al. Infect Immun 2014; Acidosis Potentiates the Host Pro-Inflammatory IL-1β Response to Pseudomonas aeruginosa Infection.
Application : WB
Reactivity : Mouse
Walle LV et al. Nature 2014; 512 (7512):69-73 Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
Application : WB
Reactivity : Mouse
Sham HP et al. PLoS Pathog 2013; 9 (8):e1003539 SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.
Application : WB
Reactivity : Mouse
Kayagaki N et al. Nature 2011; 479 (7371):117-21 Non-canonical inflammasome activation targets caspase-11.
Application : WB
Reactivity : Mouse
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