GeneTex
United States (US)

IL10 Receptor beta antibody

Cat No. GTX10778

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB, FACS, ELISA, Neut
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
FACS Assay dependent
ELISA Assay dependent
Neut Assay dependent
Not tested in other applications.

Calculated MW

37 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fragment (Human).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2, IL 10R2, IL10R2

Background

Interleukin 10, initially named cytokine synthesis inhibitory factor (CSIF), is a potent immunosuppressant of macrophage functions. IL10, a pleiotropic cytokine, exerts either immunostimulatory or immunosuppressive effects on a number of cell types, including Thy2 cells, activated fetal thymocytes, macrophages, keratinocytes, and LY-1 (CD5+) and normal B cells. IL10 stimulates the growth of stem cells, mast cells, and thymocytes and also enhances cytotoxic T cell development, costimulates B cell differentiation, and immunoglobulin secretion. Interleukin 10 binds specifically and with high affinity to cell surface receptors. Interleukin 10 receptors are members of the class II subgroup of the cytokine receptor superfamily. Mouse and human cDNA clones encoding the ligand binding IL10 receptor have been isolated. The IL10 receptor complex contains two distinct type II cytokine receptor subunits, the ligand binding IL10RA and the IL10RB. The coexpression of both chains is essential for IL10 induced signal transduction. The beta chain serves as an accessory chain essential for the active IL10 receptor complex and necessary for the initiation of signal transdunction. Interleukin 10 receptors are expressed in all cell types that are known to respond to IL10. The human interleukin 10 receptor gene maps to chromosome 11q23.3.7
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Database

SDS
PBS.pdf
Package List Price ($)
$ 319