APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1:1000 |
1:10-1:50 |
1:10-1:50 |
Not tested in other applications.
Calculated MW
Predict Reactivity
Monkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KLH conjugated synthetic peptide between 27-53 amino acids from the Central region of human IL10.
Purification
Protein A purified, followed by peptide affinity purification.
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
interleukin 10 , CSIF , GVHDS , IL-10 , IL10A , TGIF
Cellular Localization
Secreted
Background
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Database
Research Area
DATA IMAGES
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GTX80555 IHC-P Image
IHC-P analysis of human breast carcinoma using GTX80555 IL10 antibody, Internal.
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GTX80555 WB Image
WB analysis of MDA-MB435 cell lysate (35ug/lane) using GTX80555 IL10 antibody, Internal.
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GTX80555 FACS Image
FACS analysis of Jurkat cells using GTX80555 IL10 antibody, Internal. Top histogram : negative control Bottom histogram : Jurkat cells
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REFERENCE
There are currently no references for IL10 antibody, Internal (GTX80555). Be the first to share your publications with this product.
REVIEW
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