Clone JES3-9D7 is reported to act as a neutralising antibody (Othieno et al. 1999).
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant human IL-10.
Purification
Protein G purified From tissue culture supernatant
Conjugation
Unconjugated
RRID
AB_11164919
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
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![Anti-IL10 antibody [JES3-9D7] (Low endotoxin, azide free) used in Western Blot (WB). GTX39969](/upload/website/prouct_img/small/GTX39969/GTX39969_3983_WB_18121410_680.jpg "Anti-IL10 antibody [JES3-9D7] (Low endotoxin, azide free) used in Western Blot (WB). GTX39969")
![Anti-IL10 antibody [JES3-9D7] (Low endotoxin, azide free) used in Western Blot (WB). GTX39969](/upload/website/prouct_img/normal/GTX39969/GTX39969_3983_WB_18121410_680.jpg "Anti-IL10 antibody [JES3-9D7] (Low endotoxin, azide free) used in Western Blot (WB). GTX39969")