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IL12 Receptor beta1 antibody

Cat. No. GTX10781

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ELISA

Reactivity

 Human
Package
25 μg ($399)
See all IL12 Receptor beta1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.1-0.2 μg/ml
ELISA 0.5-1.0 μg/ml
Not tested in other applications.

Calculated MW

73 kDa. ( Note )

Positive Control

recombinant human IL-12 Rβ1

Product Note

The antibody shows 5% cross-reactivity with recombinant mouse IL-12 Rβ1.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

recombinant human IL-12 Rβ1 extracellular domain, expressed in NSO cells

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interleukin 12 receptor subunit beta 1 , CD212 , IL-12R-BETA1 , IL12RB , IMD30

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

Interleukin 12 (IL12) was identified as a factor secreted by human Epstein-Barr (EBV) transformed B cell lines. IL12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL12 is produced predominantly by monocytes and NK cells2 and induces T cells and NK cells to produce IFN gamma. Human IL12 is not active on mouse cells, but murine IL12 is active on both murine and human lymphocytes. IL12 signals through the IL12 receptor, which is composed of at least two subunits designated beta1 and beta2. Both IL12 receptor subunits are members of the hemapoietin receptor superfamily and have strong homology to the gp130 receptor. The beta1 receptor, although a low affinity binder of IL12, is not capable of transducing an IL12-mediated signal. A second subunit of the IL12 receptor was subsequently identified that when coexpressed with the beta1 subunit forms a high affinity receptor for IL12 and confers IL12 signaling.

Database

Research Area

REFERENCE

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SDS
PBS.pdf
Package List Price ($)
$ 399