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IL12 antibody [1-1A4]

Anti-IL12 antibody [1-1A4] used in ELISA (ELISA). GTX11446

Cat. No. GTX11446

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 1-1A4

Isotype

 IgG1

Application

 IHC-Fr, ELISA

Reactivity

 Human, Pig
Package
250 μg ($329)
See all IL12 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
ELISA 1/1,000
Not tested in other applications.

Product Note

This antibody reacts with both stimulated and unstimulated monocytes in immunohistology.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human IL-12.

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_369617

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

IL-12B Antibody , interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Antibody , CLMF2 Antibody , NKSF Antibody , CLMF Antibody , IL12B Antibody , NKSF2 Antibody

Background

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Research Area

DATA IMAGES

Anti-IL12 antibody [1-1A4] used in ELISA (ELISA). GTX11446

GTX11446 ELISA Image

ELISA analysis of pig IL-12 and human IL-12 protein(3ug/ml) using GTX11446 IL12 antibody.

REFERENCE

Application Reference

Crisan D et al. OPARU 2016; (Epub) Anti-inflammatory effect of metallic silver and gold nanoparticles complexed with polyphenolic compounds in human chronic stationary plaque psoriasis.
Application : IHC-Fr
Reactivity : Human

Clone Reference

Sindrilaru A et al. J Clin Invest 2011; 121 (3):985-97 An unrestrained proinflammatory * macrophage population induced by iron impairs wound healing in humans and mice.
Application : IHC-Fr
Reactivity : Human
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 329