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IL12B / IL12 p40 antibody [2S25]

Cat No. GTX52651

Host

Mouse

Clonality

Monoclonal

Clone Name

2S25

Isotype

IgG2

Application

WB, ELISA

Reactivity

Human
Package
100 μg ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:100 - 1:500
ELISA 1:1000 - 1:2000
Not tested in other applications.

Calculated MW

37 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The immunogen corresponding to a region within amino acids 23 - 328 of Human IL-12 p40 (Uniprot: P29460)

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CLMF , CLMF2 , IL12B , IMD28 , IMD29 , NKSF , NKSF2 , interleukin 12B , IL12 p40

Cellular Localization

Secreted

Background

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

There are currently no references for IL12B / IL12 p40 antibody [2S25] (GTX52651). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for IL12B / IL12 p40 antibody [2S25] (GTX52651). Be the first to share your experience with this product.
SDS
PBS.pdf
Package List Price ($)
$ 329