IL12B / IL12 p40 antibody

Cat. No. GTX03337

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	IHC-P
Reactivity	Human
Package	500 μl ($459)

See all IL12B / IL12 p40 products

Datasheet

View product citations for antibody GTX03337 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
IHC-P	1:50-1:100
Note : IHC-P Pretreatment : EDTA Buffer pH 8.0 for 30 min at RT

Not tested in other applications.

Calculated MW

37 kDa. ( Note )

Positive Control

Prostate

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to amino acids 5-17 of human p40

Purification

Purified IgG
From serum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interleukin 12B , CLMF , CLMF2 , IL-12B , IMD28 , IMD29 , NKSF , NKSF2

Cellular Localization

Secreted

Background

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Database

Gene ID: 3593 IL12B
UniProt: P29460 IL12B

Research Area

DATA IMAGES

GTX03337 IHC-P Image

IHC-P analysis of human lung squamous cell carcinoma tissue section using GTX03337 IL12B / IL12 p40 antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

500 μl

$ 459

Qty