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IL15 antibody [13S34]

Cat No. GTX52821

Host Mouse
Clonality Monoclonal
Clone Name 13S34
Isotype IgG1
Application WB, Neut
Reactivity Human
Package
100 μg ($329)
APPLICATION

Application Note

WB(1:500-2000)|Neutralization of IL-15 bioactivity

Calculated MW

18 kDa. ( Note )

Specificity/Sensitivity

This antibody was selected for its ability to detect human IL-15.
PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human recombinant IL-15

Purification

The IgG fraction of culture supernatant was purified by Protein G affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Interleukin 15,Il-15,Il15

Background

The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

Database

Research Area

REFERENCE
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REVIEW
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SDS
PBS.pdf
Package List Price ($)
$ 329