PBS with 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.5mg/ml(Please refer to the vial label for the specific concentration.)
Peptide corresponding to amino acids 549 to 569 of human IL-1RAcP, which differs from the sequence ofmouse origin by three amino acids (1).
Immunogen affinity purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
IL1 RAP, IL1RAP, C3orf13, FLJ37788, IL-1RAcP, IL1R3, IL 1RAcP, IL1RAcP
The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kB inducing kinase (NIK) and of NF-kB, recruits to the IL-1Rcomplex through IL-1RAcP (2). IL-1 activation of stress activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP (3,4). Like IL-1RI, IL-1RAcPsubunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.