GeneTex
United States (US)

IL1RAP antibody

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Cat No. GTX28109

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

Western blot at 1:500 to 1:1000 dilution: an approximately 66 kDa band can be detected.

Calculated MW

65 kDa. ( Note )

Positive Control

HeLa whole cell lysate

Specificity/Sensitivity

It has no cross activity to other members in the IL-1 receptor family.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide corresponding to amino acids 549 to 569 of human IL-1RAcP, which differs from the sequence ofmouse origin by three amino acids (1).

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

IL1 RAP, IL1RAP, C3orf13, FLJ37788, IL-1RAcP, IL1R3, IL 1RAcP, IL1RAcP

Background

The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kB inducing kinase (NIK) and of NF-kB, recruits to the IL-1Rcomplex through IL-1RAcP (2). IL-1 activation of stress activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP (3,4). Like IL-1RI, IL-1RAcPsubunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.

Database

Research Area

DATA IMAGES
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GTX28109 WB Image


Package List Price ($)
$ 319