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United States (US)

IL1RAP blocking peptide

Cat. No. GTX26105

Species

 Human
Package
50 μg ($139)
See all IL1RAP products

APPLICATION

Application Note

The peptide is used for blocking the activity of anti-IL-1RAcP (cat. no 8109). Incubating the peptide with equal volume of antibody for 30 min at 37ºC usually completely blocks the antibody activity in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Interleukin 1 Receptor Accessory Protein , C3Orf13 , Il-1Racp , Il1R3 , Il1Rap

Background

The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAP). IL-1RAP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor associated kinase (IRAK), which mediates activation of NF-kB inducing kinae (NIK) and of NF-kB, recruits to the IL-1Rcomplex through IL-1RAP. IL-1 activation of stress activated protein kinase and of acid sphingomyelinase also requires IL-1RAP. Like IL-1RI, IL-1RAP subunit is essential for IL-1 mediated cellular response. IL-1RAP is expressed in many tissues.

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139