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IL2 Receptor alpha antibody [B1.49.9]

Cat. No. GTX44232

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 B1.49.9

Isotype

 IgG2a

Application

 IHC-Fr, FACS

Reactivity

 Human
Package
100 μg ($399)
See all IL2 Receptor alpha products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS Assay dependent
Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Product Note

The molecular weight of the recognized antigen is 55kDa. The IL-2 receptor consists of at least three distinct membrane components: the alpha chain (IL-2R alpha, Tac, CD25), the beta chain (IL-2R beta, p75, CD122), and the gamma chain (IL-2R gamma). CD25 is undetectable on resting T cells but is induced upon T-cell activation. B1.49.9 recognizes activated T and B cells. CD25 is absent on thymocytes, resting T and B cells, and NK cells. B1.49.9 does not inhibit the in vitro IL2 dependent proliferation

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human alloactivated T lymphocytes (FC2) kept in conditioned medium.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interleukin 2 receptor subunit alpha , CD25 , IDDM10 , IL2R , IMD41 , TCGFR , p55

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399