IL2 Receptor alpha antibody [BC96] (PE-Cy7)

Cat. No. GTX01471-10
Cat. No.  GTX01471-10
Anti-IL2 Receptor alpha antibody [BC96] (PE-Cy7) used in Flow cytometry (FCM). GTX01471-10
GTX01471-10 FCM Image

FACS analysis of human peripheral blood lymphocytes using GTX01471-10 IL2 Receptor alpha antibody [BC96] (PE-Cy7).
Right panel : co-stained with IL2 Receptor alpha antibody [BC96] (PE-Cy7) and Human CD4 antibody (FITC)
Left panel : co-stained with isotype control and Human CD4 antibody (FITC)
antibody amount : 0.25 μg (5 μl)

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Anti-IL2 Receptor alpha antibody [BC96] (PE-Cy7) used in Flow cytometry (FCM). GTX01471-10
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Clone Name
    BC96
  • Isotype
    IgG1
  • Applications
    FCM
  • Reactivity
    Human, Baboon, Chimpanzee, Cynomolgus monkey, Rhesus Monkey
Summary
The BC96 antibody is specific for human CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Signaling via CD25 may modulate Th17 and Treg cell differentiation, and has been shown to play a role in the function of dendritic cells. The BC96 antibody may be used as a marker for expression of CD25 during T and B cell development, on activated mature T and B cells, and for its expression at high levels on natural T regulatory cells (nTreg cells) in the thymus or periphery, and on “induced” peripheral Tregs. This antibody is cross-reactive with CD25 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus.
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