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IL21 Receptor antibody

Anti-IL21 Receptor antibody used in Immunohistochemistry (IHC). GTX13321

Cat No. GTX13321

Host Goat
Clonality Polyclonal
Isotype IgG
Application IHC-P, ELISA, IHC
Reactivity Human
Package
50 μg ($319)
APPLICATION

Application Note

For ELISA: Use at a dilution of 1:100,000. For IHC-P: Use at a dilution of 1:300. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

59 kDa. ( Note )

Positive Control

Human lung or tonsil
PROPERTIES

Form

Liquid

Buffer

10mM Potassium phosphate, 140mM Sodium chloride, pH 7.2 containing 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide - amino acids 35-65 corresponding to N-terminus of human IL21 Receptor

Purification

Affinity purified with antigen

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Interleukin 21 Receptor,Cd360,Imd56,Nilr,Il21R

Background

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.

Database

Research Area

DATA IMAGES
Anti-IL21 Receptor antibody used in Immunohistochemistry (IHC). GTX13321

GTX13321 IHC Image

Human lung IL-21r N-Term

REFERENCE
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REVIEW
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