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IL6 Receptor antibody [3H7D3H1]

Anti-IL6 Receptor antibody [3H7D3H1] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX02130

Cat No. GTX02130

Host

Mouse

Clonality

Monoclonal

Clone Name

3H7D3H1

Isotype

IgG1

Application

Neutralizing/Inhibition

Reactivity

Human
Package
200 μg ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
Neutralizing/Inhibition Assay dependent

Note :

Neutralizing/Inhibition
The neutralization activity of this antibody is measured by its ability to neutralize IL6 Rα-mediated inhibition of proliferation in M1 cells. The Neutralization Titer (IC₅₀) is typically 0.15-0.6 μg/ml in the presence of 50 ng/ml recombinant Human IL6 Rα protein and 100 ng/ml recombinant Human IL6 protein.

Not tested in other applications.

Calculated MW

52 kDa. ( Note )

Product Note

We do not recommend use of this product for Mouse,Rat,Dog samples.

PROPERTIES

Form

Liquid

Buffer

0.2μm-filtered PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant Human IL-6R / CD126 protein

Purification

Purified by Protein A

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

interleukin 6 receptor , CD126 , IL-6R-1 , IL-6RA , IL6Q , IL6RA , IL6RQ , gp80

Background

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

Database

Research Area

DATA IMAGES

Anti-IL6 Receptor antibody [3H7D3H1] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX02130

GTX02130 Neutralizing/Inhibition Image

Enhancement of recombinant human IL6 protein (100 ng/ml) activity (IL6-dependent inhibition of cell Proliferation activity) elicited by recombinant human IL-6 Rα protien (50 ng/ml) in M1 cells is neutralized by increasing concentrations of GTX02130 IL6 Receptor antibody [3H7D3H1].
IC₅₀ : 0.15-0.6 μg/ml.

REFERENCE

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REVIEW

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Package List Price ($)
$ 329