IL7 Receptor alpha antibody

Cat. No. GTX48715

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, Dot, ELISA, IHC
Reactivity	Human, Mouse
Package	50 μg ($399)

See all IL7 Receptor alpha products

Datasheet
Document

View product citations for antibody GTX48715 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:1000-1:10000
Dot	Assay dependent
ELISA	1:5000-1:50000
IHC	Assay dependent

Not tested in other applications.

Calculated MW

52 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

20mM Potassium Phosphate, 150mM NaCl

Preservative

0.01% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Synthetic peptide corresponding to a region near the carboxy terminus of mouse IL-7 receptor protein.

Purification

Purified by antigen-affinity chromatography.
From serum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interleukin 7 receptor , CD127 , IL-7Ralpha

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.

Database

Gene ID: 16197 Il7r
UniProt: P16872 Il7r

Research Area

DATA IMAGES

GTX48715 ELISA Image

ELISA analysis of BSA-conjugated immunizing peptide using serially diluted GTX48715 IL7 Receptor alpha antibody.
Coating : 0.1 μg

GTX48715 WB Image

WB analysis of various samples using GTX48715 IL7 Receptor alpha antibody.
Lane 1 : Protein ladder
Lane 2 : Human spleen tissue lysate
Lane 3 : U251 whole cell lysate
Lane 4 : Human pancreas tissue lysate
Lane 5 : Molt-4 whole cell lysate
Dilution : 1 μg/mL

REFERENCE

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SDS
Sodium Azide.pdf

Package

List Price ($)

50 μg

$ 399

Qty