GeneTex
  • Country / Location Selection

United States (US)

IL7 antibody [M25]

Cat No. GTX14050

Host

Mouse

Clonality

Monoclonal

Clone Name

M25

Isotype

IgG2b

Application

Activation, Neutralizing/Inhibition

Reactivity

Human, Mouse
Package
500 μg ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
Activation Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

Activation
in vivo IL-7 receptor stimulation (as a complex with IL-7)

Not tested in other applications.

Calculated MW

20 kDa. ( Note )

Product Note

The M25 antibody is useful for neutralizing the bioactivity of IL-7 as well as administration of IL-7 cytokine. IL-7 administration as a complex with M25 prolongs IL-7 availability in vivo by decreasing specific and nonspecific consumption.

PROPERTIES

Form

Liquid

Buffer

0.2μm-filtered PBS (pH7)

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human IL-7

Purification

Protein G purified
From tissue culture supernatant

Purity

>95% (Determined by SDS-PAGE)

Endotoxin

<0.002EU/μg (Determined by LAL gel clotting assay)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

IL7,interleukin 7

Cellular Localization

Secreted

Background

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Database

Research Area

REFERENCE

There are currently no references for IL7 antibody [M25] (GTX14050). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for IL7 antibody [M25] (GTX14050). Be the first to share your experience with this product.
Package List Price ($)
$ 379