APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:2000 |
| 1:10 - 1:100 |
| 1:50 - 1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human IMPA1 (NP_005527.1).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
inositol monophosphatase 1 , IMP , IMPA , MRT59
Cellular Localization
Cytoplasm
Background
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Database
Research Area
DATA IMAGES
|
GTX54348 ICC/IF Image
ICC/IF analysis of A549 cells using GTX54348 IMPA1 antibody.
Blue : DAPI
|
|
|
GTX54348 IHC-P Image
IHC-P analysis of mouse testis tissue using GTX54348 IMPA1 antibody.
Dilution : 1:100
|
|
|
GTX54348 IHC-P Image
IHC-P analysis of rat kidney tissue using GTX54348 IMPA1 antibody.
Dilution : 1:100
|
|
|
GTX54348 WB Image
WB analysis of various sample lysates using GTX54348 IMPA1 antibody.
Dilution : 1:1000
Loading : 25μg per lane
|
|
|
GTX54348 IHC-P Image
IHC-P analysis of human colon tissue using GTX54348 IMPA1 antibody.
Dilution : 1:100
|
REFERENCE
There are currently no references for IMPA1 antibody (GTX54348). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for IMPA1 antibody (GTX54348). Be the first to share your experience with this product.
