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IQSEC2 antibody

Anti-IQSEC2 antibody used in IHC (Paraffin sections) (IHC-P). GTX32143
Anti-IQSEC2 antibody used in Western Blot (WB). GTX32143

Cat No. GTX32143

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA
Reactivity Human, Mouse, Rat
Package
100 μg ($329)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

163 kDa. ( Note )

Positive Control

SK-N-SH Cell Lysate(GTX23956)

Specificity/Sensitivity

At least two isoforms of IQSEC2 are known to exist; this antibody will only detect the larger isoform. IQSEC2 antibody is predicted to not cross-react with IQSEC1.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

IQSEC2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IQSEC2.The immunogen is located within amino acids 1380 - 1430 of IQSEC2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

IQ motif and Sec7 domain 2 , BRAG1 , IQ-ArfGEF , MRX1 , MRX18 , MRX78

Cellular Localization

Cytoplasm

Background

This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Database

DATA IMAGES
Anti-IQSEC2 antibody used in IHC (Paraffin sections) (IHC-P). GTX32143

GTX32143 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX32143 IQSEC2 antibody.
Working concentration : 5 μg/ml

Anti-IQSEC2 antibody used in Western Blot (WB). GTX32143

GTX32143 WB Image

WB analysis of SK-N-SH cell lysate using GTX32143 IQSEC2 antibody.
Working concentration : 1 μg/ml

REFERENCE
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Package List Price ($)
$ 329