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United States (US)

IRAK1 peptide

Cat. No. GTX26230

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($139)
See all IRAK1 products

APPLICATION

Application Note

The peptide is used for blocking the activity of anti-IRAK (cat. no 238). Incubating the peptide with equal volume of antibody for 30 min at 37ºC usually completely blocks the activity of anti-IRAK in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Interleukin 1 Receptor Associated Kinase 1 , Irak , Pelle , Irak1

Background

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in the IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139