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United States (US)

IRAK2 peptide

Cat. No. GTX26232

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($139)
See all IRAK2 products

APPLICATION

Application Note

The peptide is used for blocking the activity of anti-IRAK2 (cat. no GTX26148). Incubating the peptide with equal volume of antibody for 30 min at 37ºC usually completely blocks the antibody activity in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Interleukin 1 Receptor Associated Kinase 2 , Irak-2 , Irak2

Background

The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kB activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation. Members in the IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139