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IRF4 / MUM1 antibody [EAU32]

Anti-IRF4 / MUM1 antibody [EAU32] used in IHC (Paraffin sections) (IHC-P). GTX01894

Cat. No. GTX01894

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 EAU32

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($419)
See all IRF4 / MUM1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:2000

Note :

IHC-P
Heat Induced Epitope Retreival (HIER) was performed in Epitope Retrieval Solution pH 9.
Not tested in other applications.

Calculated MW

52 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to 313 amino acids of the human multiple myeloma oncogene 1 (MUM-1) molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

interferon regulatory factor 4 , LSIRF , MUM1 , NF-EM5 , SHEP8

Cellular Localization

Nucleus

Background

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Database

Research Area

DATA IMAGES

Anti-IRF4 / MUM1 antibody [EAU32] used in IHC (Paraffin sections) (IHC-P). GTX01894

GTX01894 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX01894 IRF4 / MUM1 antibody [EAU32]. Note nuclear staining of B cells showing lymphoplasmacytic differentiation.

REFERENCE

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REVIEW

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Package List Price ($)
$ 419