APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 - 1 μg/mL |
| 5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
HEK293 Cell Lysate(GTX27902)
Product Note
This antibody is specific for IRF7 Internal
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF7.The immunogen is located within amino acids 220 - 270 of IRF7.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
interferon regulatory factor 7 , IMD39 , IRF-7 , IRF-7H , IRF7A , IRF7B , IRF7C , IRF7H
Cellular Localization
Nucleus,Cytoplasm
Background
Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
Database
Research Area
DATA IMAGES
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GTX85489 WB Image
WB analysis of 293 cell lysate using GTX85489 IRF7 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml
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GTX85489 IHC-P Image
IHC-P analysis of mouse spleen tissue using GTX85489 IRF7 antibody.
Working concentration : 5 μg/ml
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REFERENCE
There are currently no references for IRF7 antibody (GTX85489). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for IRF7 antibody (GTX85489). Be the first to share your experience with this product.
