APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.2-2.5 ug/ml |
2-10 ug/ml |
Not tested in other applications.
Calculated MW
Positive Control
human ovary tumor , Jurkat
PROPERTIES
Form
Liquid
Buffer
1x PBS, 2% Sucrose
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide corresponding to a N-terminal region of Human IRF8
Purification
Affinity Purified
Conjugation
Unconjugated
RRID
AB_424843
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
interferon regulatory factor 8 , H-ICSBP , ICSBP , ICSBP1 , IMD32A , IMD32B , IRF-8
Cellular Localization
Nucleus,Cytoplasm
Background
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX77895 WB Image
WB analysis of Jurkat cells using GTX77895 IRF8 antibody at 0.2-1μg/ml.
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GTX77895 WB Image
WB analysis of human ovary tumor tissue using GTX77895 IRF8 antibody at 1μg/ml.
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GTX77895 IHC-P Image
IHC-P analysis of human intestine tissue using GTX77895 IRF8 antibody at 4.0-8.0μg/ml.
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GTX77895 IHC-P Image
IHC-P analysis of human liver tissue using GTX77895 IRF8 antibody at 4.0-8.0μg/ml.
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REFERENCE
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REVIEW
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