GeneTex
United States (US)

IRS1 (phospho Ser639) antibody

GTX38614_20190129_IHC-P_19012901_312.jpg
GTX38614_20190129_WB_19012901_853.jpg

Cat No. GTX38614

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:1000
IHC-P 1:50-1:100
Not tested in other applications.

Calculated MW

132 kDa. ( Note )

Specificity/Sensitivity

This antibody detects endogenous levels of IRS1 only when phosphorylated at serine 639.
PROPERTIES

Form

Liquid

Buffer

PBS (without Mg2+ and Ca2+) pH 7.4, 150mM NaCl, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human IRS1 around the phosphorylation site of serine 639 (P -K-S(p)-V-S).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Insulin Receptor Substrate 1,Hirs-1,Irs1

Background

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

Database

Research Area

DATA IMAGES
GTX38614_20190129_IHC-P_19012901_312.jpg

GTX38614 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX38614 IRS1 (phospho Ser639) antibody.

GTX38614_20190129_WB_19012901_853.jpg

GTX38614 WB Image

WB analysis of 293 cell lysate using GTX38614 IRS1 (phospho Ser639) antibody.

Package List Price ($)
$ 219